Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0307717
PubChem CID
Molecular Formula
C5H11N3S
Molecular Weight
145.231 g/mol
Synonyms/Alias
[CHEMBL48338; Pyrrolidin-1-yl-thiourea; N-Pyrrolidin-1-ylthiourea; 88147-87-9; SCHEMBL5320211; DTXSID20658163; BDBM50224231]
InChI Key
LUZJFNYVKQEEGM-UHFFFAOYSA-N
InChI
InChI=1S/C5H11N3S/c6-5(9)7-8-3-1-2-4-8/h1-4H2,(H3,6,7,9)
IUPAC Name
pyrrolidin-1-ylthiourea
CAS Number
88147-87-9

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

20 20 0 0 0 0 0 0 0 0999 V2000
-2.0263 0.4493 -0.4340 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.8817 0.0728 1.0294 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.4162 0.306...

Experimental Data

Activity Data

Target Ion Channel
Transient receptor potential cation channel subfamily V member 1/2/4
Uniprot Accession Number
Function
Antagonist
Species
Homo sapiens (Human)
IC50
IC50: 3000 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.4
Holding Potential
Not specified
Temperature
Room Temperature
Test Method
Fluorometric Imaging Plate Reader (FLIPR) Membrane Potential Assay
Test Species
Rattus norvegicus DRG neurons

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
9
Rotatable Bonds
1
logP
-0.1696
Complexity
40.7281
TPSA (Ų)
41.29
H-Bond Donors
2
H-Bond Acceptors
2
Ring Count
1
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